Bergamot Bioactive Polyphenolic Fractions (BPF) promotes healthy cholesterol levels with a unique blend of cholesterol-balancing and cardio-protective polyphenolic flavonoids.
Emerging clinical research shows that BPF helps support healthy:
BPF has also been shown to provide antioxidant and anti-inflammatory properties to support cardiovascular health and arterial elasticity.
Contains: 60 capsules, 30 servings
Directions: 2 capsules daily or as recommended by your health care professional
Gliozzi M, Walker R, Muscoli S, Vitale C, Gratteri S, Carresi C, Musolino V, Russo V, Janda E and Ragusa S. Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia. International journal of cardiology. 2013;170:140-145.
Toth PP, Patti AM, Nikolic D, Giglio RV, Castellino G, Biancucci T, Geraci F, David S, Montalto G and Rizvi A. Bergamot Reduces Plasma Lipids, Atherogenic Small Dense LDL, and Subclinical Atherosclerosis in Subjects with Moderate Hypercholesterolemia: A 6 Months Prospective Study. Frontiers in pharmacology. 2015;6.
Mollace V, Sacco I, Janda E, Malara C, Ventrice D, Colica C, Visalli V, Muscoli S, Ragusa S and Muscoli C. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies. Fitoterapia. 2011;82:309-316.
Di Donna L, Iacopetta D, Cappello AR, Gallucci G, Martello E, Fiorillo M, Dolce V and Sindona G. Hypocholesterolaemic activity of 3-hydroxy-3-methyl-glutaryl flavanones
enriched fraction from bergamot fruit (Citrus bergamia):“In vivo” studies. Journal of Functional Foods. 2014;7:558-568.
Campolongo G, Riccioni CV, Raparelli V, Spoletini I, Marazzi G, Vitale C and Volterrani M. The combination of nutraceutical and simvastatin enhances the effect of simvastatin alone in normalising lipid profile without side effects in patients with ischemic heart disease. IJC Metabolic & Endocrine. 2016;11:3-6.
Cappello A, Dolce V, Iacopetta D, Martello M, Fiorillo M,Curcio R, Muto L and Dhanyalayam D. Bergamot (Citrus bergamia Risso) Flavonoids and Their Potential Benefits in Human Hyperlipidemia and Atherosclerosis: an Overview. Mini reviews in medicinal chemistry. 2015.
Giglio RV, Patti AM, Nikolic D, Volti GL, Al-Rasadi K, KatsikiN, Mikhailidis DP, Montalto G, Ivanova E and Orekhov AN. The effect of bergamot on dyslipidemia. Phytomedicine.
Janda E, Lascala A, Martino C, Ragusa S, Nucera S, Walker R, Gratteri S and Mollace V. Molecular mechanisms of lipid-and glucose-lowering activities of bergamot flavonoids.
Mollace V, Ragusa S, Sacco I, Muscoli C, Sculco F, Visalli V, Palma E, Muscoli S, Mondello L and Dugo P. The protective effect of bergamot oil extract on lecitine-like oxyLDL receptor-1 expression in balloon injury-related neointima formation. Journal of cardiovascular pharmacology and therapeutics. 2008;13:120-129.
Risitano R, Currò M, Cirmi S, Ferlazzo N, Campiglia P, Caccamo D, Ientile R and Navarra M. Flavonoid fraction of Bergamot juice reduces LPS-induced inflammatory
response through SIRT1-mediated NF-κB inhibition in THP-1 monocytes. PLoS One. 2014;9:e107431.
Trombetta D, Cimino F, Cristani M, Mandalari G, Saija A, Ginestra G, Speciale A, Chirafisi J, Bisignano G and Waldron K. In vitro protective effects of two extracts from bergamot peels on human endothelial cells exposed to tumor necrosis factor-α (TNF-α). Journal of agricultural and food chemistry. 2010;58:8430-8436.
Benson J. ALTERNATIVE MEDICINE CABINET: Bergamot. Alternative Medicine. 2015:49.