Size: 76 Vegetarian Capsules
Multivitamin and Mineral Supplement Formulated to Support Balanced Phase I and Phase II Liver Detoxification*
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Detox Multi supports daily detoxification for optimal vitality and health. This formula provides methylated B12 and folate along with comprehensive bifunctional nutritional and herbal support designed to balance and enhance the activities of liver detoxification enzymes in the Phase I and Phase II pathways.*
- Provides Protection Against Free Radicals Produced During Natural Detoxification*
- Supports Nutritional Adequacy for Optimal Enzyme Function*
- Promotes Overall Well-Being by Supporting Balanced Detoxification*
- Boosts Liver Detoxification Pathways with Concentrated Herbal Extracts*
- Supports Health During Natural Weight Loss*
In the modern world, we are regularly exposed to toxins in our air, water, and food. Since many toxins are fat soluble, they can be stored in body fat and then released during weight loss, impacting our health. The liver has intricate and powerful tools in the phase I and II detoxification pathways to eliminate toxins from the body, but it can’t do its work alone. The liver needs the right balance of nutrients to promote healthy detoxification and protect our cells from the damaging effects of toxins. Detox Multi provides complete nutrient support for balanced detoxification, fortified with specialized herbal extracts to promote the targeted elimination of environmental toxins.*
*These statements have not been evaluated by the FDA and are not intended to treat or cure any disease.
We love Detox Multi because it leverages the power of both nutrients and herbs to support detoxification and overall wellness:
- Pomegranate, green tea extract, and the specialized amino acid N-acetyl-cysteine promote the production and function of glutathione, our most important detox antioxidant, for healthy Phase I and Phase II activity.
- Artichoke, milk thistle, and the amino acid taurine support optimal liver function and sustain healthy bile flow to ensure toxin elimination.
Watercress and sulfur enhance the activity of crucial Phase II conjugation enzymes.
2 CAPSULES PER SERVING
Vitamin A (from mixed carotenoids†† and retinyl palmitate) 750 mcg Vitamin C (as ascorbic acid) 133 mg Vitamin D (as cholecalciferol) 33 IU Vitamin E (as d-alpha tocopheryl succinate) 44.6 mg Thiamin (as thiamin mononitrate) 10 mg Riboflavin 5 mg Niacin (as niacinamide and niacin) 23.3 mg Vitamin B6 (as pyridoxine HCI) 16.66 mg Folate (as calcium L-5-methyl-tetrahydrofolate) 445 mcg DFE Vitamin B12 (as methylcobalamin) 33.4 mcg Biotin 66 mcg Pantothenic Acid (as d-calcium pantothenate) 33.3 mg Zinc (as zinc citrate) 6.5 mg Selenium (as selenomethionine) 50 mcg Copper (as copper citrate) 0.65 mg Manganese (as manganese citrate) 1.66 mg Molybdenum (as molybdenum aspartate) 66 mcg Sodium (as sodium sulfate) 40 mcg Artichoke (Cynara scolymus) Leaf Extract (containing cynarin and chlorogenic acid) 167 mg Watercress (Nasturtium officinale) Aerial Parts 4:1 Extract 133 mg Taurine 117 mg Sodium Sulfate 100 mg Pomegranate (Punica granatum L.) Whole Fruit Extract [standardized to 45.8 mg gallic acid equivalent (GAE)] 87.5mg N-Acetyl-L-Cysteine 67 mg Decaffeinated Green Tea (Camellia sinensis) Leaf Extract [standardized to 60% (33.6 mg) catechins and 40% (22.4 mg) epigallocatechin gallate (EGCG)] 56 mg Silymarin (from milk thistle seed extract, Silybum marianum) 50 mg
Other Ingredients: Capsule (hydroxypropylmethylcellulose), microcrystalline cellulose, magnesium stearate (vegetable), and silica
Take 2 capsules once daily or as directed by your healthcare practitioner.
Caution: If pregnant or nursing, or taking medications, consult your healthcare practitioner before use.
Polyphenols are probably antigenotoxic on account of their antioxidant activities and might alter phase I and II enzymes in a way that results in chemoprotection. We investigated the hypothesis that polyphenols enhance expression of glutathione S-transferases (GSTs), which increases carcinogen detoxification and thereby provides protection against oxidative stress. HGSTP1 protein expression and GST polymorphisms were determined in leucocytes obtained during an intervention study with healthy subjects consuming two fruit juices in an 8 wk trial (polyphenol-free run in phase, juice intervention phase, washout phase, second juice intervention phase, each treatment regime lasted for 2 wk). The study had originally shown that juice intervention significantly reduced oxidative DNA damage in leucocytes at week 8 (Bub, A., Watzl, B., Blockhaus, M., Briviba, K. et al., J. Nutr. Biochem. 2003, 14, 90-98). We reanalysed the levels of DNA damage based on GST genotypes. We also treated leucocytes in vitro with mixtures of polyphenols and determined cytotoxicity and expression of 96 genes related to drug metabolism. Key results with leucocytes of the intervention study were that the initial content of hGSTP1 protein was first suppressed at weeks 4 and 6. At week 8, however, hGSTP1 protein expression was significantly increased. HGSTP1 protein levels and DNA damage were inversely correlated (p = 0.005), but there was no difference for cells obtained from subjects with hGSTM1*1 and hGSTM1*0 genotypes, nor was there any difference between cells from subjects consuming the two different juices. The treatment of leucocytes with polyphenol mixtures in vitro did not result in modulated GST gene expression or total GST activity, but in an up-regulation of other biotransformation enzymes (e. g., members of the cytochrome P450 and the sulphotransferase family). In conclusion, in vitro treatment of leucocytes led to a modulated mRNA expression of selected genes, not directly related to oxidative defence systems. In vivo, however, we observed a delayed enhancement of hGSTP1, which could be associated with an initial repression of oxidative DNA damage in leucocytes from human subjects, consuming juices with high levels of polyphenols.
Organisms must confront various environmental stresses. The liver is central to protecting against such stresses in mammals, and it has many detoxification and anti-oxidative stress functions. Radiation is a source of oxidative stress and is known to affect the liver and induce anti-oxidative responses. The detoxification enzyme rhodanese, which is also called thiosulfate sulfurtransferase (TST), has been demonstrated to be induced in the liver in response to radiation. Cyanide detoxification is a function of the liver, and rhodanese is a key enzyme involved in sulfur metabolism in that detoxification. Though the anti-oxidative stress system in which sulfur molecules such as thiol compounds are involved has attracted attention as a defense against radiation, detoxification enzymes may have other roles in this defense. Understanding how these functions are affected by alterations of sulfur metabolism (including thiol compounds) after irradiation would help uncover their roles in defense against cancer and other deleterious health effects, as well as environmental stress responses. This article reviews the roles of sulfur-related metabolism in oxidative stress regulation and detoxification for recovery from liver damage after radiation exposure, with particular attention to recent findings of sulfur-related enzymes such as rhodanese, which is unique in sulfur metabolism.