HistDAO

Targeted Support for Digestive Histamine Breakdown

Histamine plays many roles in the body—from immune response to digestive function—but for some individuals, excess histamine from food can cause discomfort such as bloating, flushing, headaches, or skin sensitivity. HistDAO™ provides clinically studied diamine oxidase (DAO), the primary enzyme responsible for breaking down dietary histamine in the small intestine.

DAO helps maintain histamine balance in the digestive tract by neutralizing histamine from foods such as aged cheese, wine, tomatoes, and fermented products. Unlike antihistamines that act systemically, HistDAO works exclusively in the gut where it’s needed most. It does not affect immune-related (IgE) food allergies.

Highlights

• Supports breakdown of food-derived histamine in the digestive tract*
• Enhances DAO enzyme activity at the site of histamine exposure (gut lining)*
• Helps relieve occasional histamine-related digestive and skin symptoms*
• Supports gastrointestinal comfort when consuming high-histamine foods*
• Ideal for individuals with histamine intolerance or DAO deficiency*
• Contains 20,000 HDU DAO per 2-capsule serving plus vitamin C for antioxidant support*

Why We Recommend It

We recommend HistDAO when patients show signs of histamine intolerance but don’t have classic food allergies. It’s a well-tolerated, effective solution to help reduce reactions to high-histamine foods and promote digestive ease.

*These statements have not been evaluated by the FDA and are not intended to treat or cure any disease.